Megacorporate Fortress: Stories of Greed and Greed.
Depot becomes Loading Dock. Diplomats become Salesmen. Crafts become Export goods. Research facilities.
And milita becomes security.
SINless "citizens" are executed or forced into labor as necessary.
Possible megaprojects include building a skyscraper, paving all the town's roads, making a stripmine for exportation (with "criminals" forced to work for you), and generally pissing off the Amerinds by cutting down all their trees.
Bonus Points: Tribal organizations, Smuggler rings, and Nation States as possible "Fortress" types
Adventure mode criminals could be called Runners, and only Mr Johnson has the tags that would make him a quest giver. Tho adventure mode would work WAY better with Nightclubs (tavern alternate name)
Goblinization is a somewhat rare occurance in the age of 2050, but it doesn't have to be like that. To ensure some metahumans in your fortress, you could model all the different races as castes. Since they're all homo sapiens somethingelseis, they would work pretty good as rare castes and maybe a separate creature type for the ones who run their own nations other than humans (elf caste, but also an elf creature)
If you're playing as a Humanis Policlub member, you can then just execute the "freaks" that are born to your pure race of hillbillies.
Or at least, that's how it could work.