I was having a grand old time, figuring out how to make and shoot bows at zombies. I had yet to find a safe spot to make a base, the initial safehouse being too close to zombies, and spent half a day skirting around giant ant territory. By nightfall I still hadn't found a shelter. Unwilling to blindly stumble around in the dark, I, as a heavy sleeper, went to sleep by the side of the road. I woke up a short time later with a giant ant biting my face, grabbed a spear, and somehow survived. Now having nearly no head HP, I continued along the side of the road for another half an hour or so, ran into a bear, somehow killed the bear, and went back to sleep.
I woke up, alive, the next morning! ... In retrospect, spending time exploring the storage building for radioactive waste I found shortly afterwards was not a good plan. Spending time practicing crafting on the scrap inside was even worse.
Next guy, new world! Similar problems. I found a one-shot rocket launcher on the first day, and brought it with me for laughs. Still no shelter by nightfall. Not knowing how to fight, I couldn't hit a coyote that was slowly killing me. I took the only sane action, which succeeded. The explosion brought a giant spider on me, and I fell.