That's the thing, after you get some equipment things pretty much wind down to BOO!! effect horror and it becomes an ordinary shooter, what i would really want is the game retaining that pressure and horror of the Zone no matter how awesomely equipped you are, anomalies should stay somewhat rare, in certain places and become insanely deadly, the best suit protecting you once at most.Now this could make gameplay tedious with constant trips to repair your stuff, but it could be solved with a party system of sorts where you travel with your mates, find stuff, sell it each of you has some sort of skill beneficial to the team.Also guns should be toned down a lot, not the firepower itself but more their frequency so that finding a working weapon is quite an acomplishment.
But that would probably require a big change in the story of the Zone since military, mercenaries and bandits are very established by now, unless the sequel is actually the prequel in which case they can do some very neat stuff with the Zone itself aswell as with the people.
There are mods that do much of this, and I actually very nearly began my own mod project for Call of Pripyat which would have had a complete focus on pure survivalism in a less populated zone.
In fact, here is my old thread where I talked about it. I wanted to make good equipment a purely temporary thing because it would get lost, stolen, or broken... and make hunger, disease, and wounds more serious problems. Most of the stuff I proposed has been done, or close enough to prove the possibility... I just wanted to put it together.
Then I found Dwarf Fortress... so much for that