Well, yeah. You have to be more careful about where you place your services. What I do is basically imagine the whole system as a stream. Services that send out vehicles are built upstream of where they need to go, and things like schools are built downstream of the residences. Residences are built downstream to the main entrance, and commercial downstream of residential, so that the residents can shop easily. Industries have to have two way roads, in my experience, since they sometimes deliver to each other, and the entrance to the district should be built downstream of the residences and closest to the exit, so they don't obstruct traffic.
All I can really say is to get a hang of how traffic flows and how to manipulate it. The good thing about one-ways is that it's really easy to make traffic go where you want it, and public transport is a breeze. Most of my traffic problems happen when my heavy traffic decides to take a shortcut that was not meant for those loads, which is easily solved by moving or removing a few intersections, or by replacing them with elevated roads. My most complex design right now is basically a giant oval roundabout with flat sides, built around a highway, with concentric half-circles of one way roads expanding out the sides, and with strategically placed intersections to shorten the trip without obstructing the flow. It's big, pretty, and works really, really well (except for deathcare. Fuck deathcare). I'll post screenshots later.
Edit: Actually, I've posted the entire city. Enjoy:
http://steamcommunity.com/sharedfiles/filedetails/?id=410329999&searchtext=