Well it depends upon what you are asking for. If you just took a normal gobs-o-H.P. game and made the maximum-life static, then it would be stupidly lethal as everything would very rapidly reach one-hit-kill territory and it would end up being ruled over by fast area effects that shoot around corners. now this may be realistic, but doesn't make for a game that is both fun and epic.
Alternatively you could make the total combined stats static and make power-creep a purely customisation thing, letting folk spam the life bar if they wanted, but forcing them to drop other aspects to do it.
You could just have a fairly small power differential, I believe that in Shadowrun Returns you can start with enough max health to last the whole game... I forget the specifics of Vampire the Masquerade: Bloodlines, though I suspect that the amount of incoming damage probably went up by about a factor of three to five as far as serious battles went, you can probably afford to skimp on the longevity upgrades...
Then again you could have alternative defences, you die in three hits at the start and end but by the end you have 99% damage avoidance chance with three retries and always get a half-dozen opportunities to get to safety between any attacks...
Honestly, I just wish that enemies never had enough longevity for things to become repetitive...
I wish for a sequel to Iji,,,