Well... I did have an idea for some sort of successor that doesn't just stick to the "magical hormonal teenagers + enclosed spaces = !!FUN!!" formula. Anyone familiar with /tg/'s
CATastastrophe setting? It's that, except with all the magical realm elements removed, and with influences from Roadside Picnic instead.
So basically what's happened is that, due to various natural disasters, humanity went extinct and the world's flooded. Eventually, the AIs that helped run the world managed to make it human hospitable again, and using stored genetic and neurological data, began to "revive" their old masters. Issue is, it's taken centuries and all this time, the AIs have been running everything with no human oversight at all.
Entire metropolises now thrive on ocean floor, filled with technology so advanced it seems almost supernatural. The shops are filled with specters, mindless androids that exist for the sole purpose of filling in for the missing customers. Imageboards and forums churn with activity, fueled by ever-developing AI who exist for the sole purpose of keeping them filled with human-like content. With prices topping the sharemarket are companies you've never heard of, in industries you've never heard of, the trading floor abuzz with activity that now happens faster than your mind can even process. Humanity has been replaced. Not out of malice nor spite, but simply because
someone had to buy the products, make the transactions, and be monitored by the surveillance systems.
And more pressingly, the greatest issue of them all, is that they neglected to give you any of this information when they revived you. You have no idea how their technology works, or even how to communicate with them because they apparently decided to change every single communication protocol without thinking to tell anyone about it. They'll keep you alive, and, relatively comfortable, but right now that's the extent of it.
What the actual players do will still be pretty much the same as the CATastrophe setting, which is to say, laze about, working on odd jobs related to maintaining/developing their settlement (probably in a more Harvest Moon vein than a fetch-quest vein), and diving down to the AI-run cities in order to try and steal stuff (because you have no idea what currency they even use now) without getting tased (okay, not actually tased, but basically the same overall result), arrested and deported (because your passport expired a few centuries ago and they don't tell you how to apply for a new one) back to settlement empty-handed.
Loot will basically just consist of artifacts with strange properties and varying degrees of usefulness. Varying between something that causes odd but ultimately inconsequential specific events to happen to everyone who encounters the user (a device of unknown purpose), to a small perpetual motion machine that can be used for power supply or as a motor (a desk toy).