So, Synthetic Civilization.
Compared to the current Intelligences of Civilization, the Primal Intelligence was actually rather primitive and crude. Still, the fact that a chance interface between barely functional, emergency-power only damage control systems of the wreckage of what was Terran, Merope, and Kai fleets on a planet uncomfortably close to the active sun became an AI that laid down the Alpha Codes of Civilization and dissolved itself into the fifteen thousand subordinate intelligences is something that the AI "descendants" take pride in and consider an example. They're cheerfully mercenary and also officially diplomatic to all partially due to being small and low on the totem pole. Bodies are not entirely important to them aside from utility, although there is a growing movement towards bodies and environmental conditions as a form of art aside from the "Visualization of the All" logic exercise. There are millions of original Intelligences by now and countless clones, backups, copies, etc. Despite their being friendly to other nations, Synthetic Civilization does engage internally in what would be considered biological warfare to a flesh and blood creature on a regular basis as a self-checkup and to increase pressure to reproduce. After all, they can always quarantine, restore from backup, study the infected copy, cure the virus, merge saves...
Unfortunately, the League views the Civilization as science fiction nightmares just waiting to happen because of their mercenary attitude, and they did come up with the theory that Octav weapons could cause a nova, which eventually lead to the Merope possessing a hyper-capable megastation capable of annihilating systems. This managed to turn a former friendly relationship with the Octav that was leading to their alliance with the Kai being expanded into a deep neutral confusion and discussion of the responsibility of the Synthetics that could go either way. The Empire is starting to sniff around the edges of Civilization, and the Civilization is in definite consensus that the Red Stars are the biggest immediate threat.