For me, it would be more interesting to have a game that starts around the industrial revolution, and allows player to contribute to or direct an alternate history where the player(s) could affect how government / regulation develops (e.g. by influencing the people in power, or voters, etc), in addition to making choices regarding wages and prices. Regulation, and company policy, could cover things like using things during production which are harmful to workers, or things that are harmful to the consumer (such as lead), how much to spend avoiding pollution, workplace safety, compensation for injured workers, and various other things that a company would have to decide on.
A way to enable tweaking government policy would be to allow players to move between corporations, lobbying, and government, much like people do in the real world.
All of that could factor into how people in the simulation live, how healthy they are, how educated they are and how well off they are, how fast resources are being depleted, soil depletion (farming methods used), pollution of waterways (farm runoff and other pollution), etc.
I'd also include energy policy and global warming as something that could be included and modeled (trying to find ways to avoid it could be a goal, especially if most companies in the game are purely profit driven).
Problems with all this: This is all getting really complicated and I for one understand little about how you could accurately simulate any of that (it seems like economists can't even agree on what a certain policy is going to do, which could present problems with trying to figure out how to accurately model anything).
I have no idea whether there's a market for this kind of game, whether singleplayer or not.