The gradual spread of Tiberium and change of landscapes would probably be difficult if not impossible.. Because of CK limits.. I think?
Actually, I think it may be possible. It would be kind of "hacky" and would probably require a fake terrain be triggered to appear on top of the real terrain. It might also cause tons of lag, since it'd need to spawn a lot of stuff.
It WOULD cause a lot of lag...so many scripts would be needed for that, that it probably completely break most if not all skyrim setups. Except maybe pure vanilla and only that mod added onto it...
Also, it is 100% my video card not having enough Vram for my overhaul. It hits 2gb cap pretty quick (which is normal in a heavy load setup), then goes to my system ram due to running out of vram...and bam...crash. All the mods play fine as far as I can tell...but...yeah...hope I can upgrade to the 4gb 970 gtx at some point soon. Its a tad out of my budget sadly, which sucks cause it is actually a pretty good price for a great card.
In any case, I'll have to have a warning when I upload it (whenever I upgrade my video card) that it isn't playable on anything less than 4gb video card. And probably need the 700 or new 900 series (or titan...) for it to be playable at all. My 660 GTX barely stays at 30 fps average and not enough vram. So guess the overhaul is more higher end than I intended...even without ENB...ah well...