I want an interplanetary strategy game based around assassination; you lead what is functionally a galactic assassins guild, like the Genohardan from KOTOR. You take contracts, arrange missions, utilising operatives with various skills, contacts and resources, and your reputation rises and falls depending on the success of contracts.
Contracts are how you make money and establish yourself. But the real meat of the game lies in the sandbox-y nature of the galaxy, which has its own factions, planet populations, ideologies, economies, wars, all of which involve important individuals who can be killed. By selecting certain individuals for death, you can unmake entire sections of the galaxy, enterprises that could have worked crumble with one laser bolt to the head. You can prevent wars, cures from being made, all sorts of galactic simulation goodness.
Your ability to gather information is dependent on your network of informants ( and how much money you spend on them ) and therefore flawed. This entire game is about the consequences of the killings you sanction, and dealing with other factions who may want to put your Space Dark Brotherhood out of commission. You can't really survive very long brazenly killing political/business/religious/military leaders all willy-nilly, so secrecy is your best shield. Apart from that, the galaxy is your playground.