I too am getting the problem where hitting ESC does nothing after dying in Adventure Mode. I held down the key for 10 minutes by propping up some junk on my keyboard, with no success. After that I gave up and Ctrl-Alt-Del'd out of the game.
Me too. Forced save scumming
EDIT: In fact, it would appear that none of the keys do anything. Normally, after death, when one presses the keys for temperature, weather or date a message appears. This doesn't seem to be happening. Also, unlike 40d, time seems to go on after you are dead. (Elves running around etc.)
I'm not sure whether this is the same problem or not, but I'm getting (part of?) the keyboard locked up sometimes as well, one occasion, I could hit ESC to get tot he menu, but not select anything on there, or navigate the menu. the other time I couldn't even do that, couldn't get out of the mode I was in, which IIRC was mining, as I remember I couldn't designate any further mining.
annoying, as there's nothing else you can except kill the process.
system is - Vista 64 Home Premium - Intel Core2 Quad CPU W8200 - Geforce GTS 120 - Standard PS2 keyboard
I'll try and isolate the exact circumstances, but it's very finicky, I play every day and it's only happened a couple of times since i upgraded to 40d16, still, I'm making notes as I hit the problem, so if it continues, I might be able to find a repro case.