Alright, just had a hilarious exploration run and snooped around a couple areas I hadn't been to before. So, basically, I spent an incredible amount of time accomplishing basically nothing!
Thanks to a lucky combination of getting Breathless as my second perk (and Personal Shield as the first, love that thing) and picking up a wand with lava to blood and another wand with rapid-fire magic bolts (the green unlimited ones with the +critchance), I managed to chew my way down through the lava in the volcano to grab the nuke orb. Still haven't used nuke, but I've sure picked it up a bunch of times!
Then once I'd basically emptied the caldera (an incredibly tedious process due to how lava to blood actually works in practice), I swung my way up around and, with just a teensy dash of stolen polymorph potion (there was a vat of it in the world, I just tapped a little bit into an empty flask by making a puddle and gently tossing the flask into it) made my way up and over the tree.
From there, I made the long and slow trek across the wastes and jumped into the lake, then tortured myself with swimming down the whole way to the essence chamber... Cracked open the essence chamber with the magic bolts (thank goodness those things can dig; wouldn't have been able to do any of this without that), and grabbed... Essence of Spirits.
Despite the descriptive text of "This was not a good idea", it's by far the most harmless of the essences I've seen thus far. It's actually even helpful, which can't be said of most of the others.
After grabbing that and making the equally dull slog up to the surface, I hopped back over the tree, inebriated and destroyed the welcoming committee that had spawned (screw those things, seriously. What's even the point?), then walked aaaaaaall the way back across the map to get to the pyramid. Nabbed the only interesting wand in there, got some corpseflies drunk, and then did the easter egg of summoning the secret spider boss. Tried shooting at it a few times, couldn't even seem to damage it, walked back and forth a little and the spider apparently disappeared into both the underground (I could hear things shooting at it) and the sky (I got a couple energy blasts fired at me from above after a while) simultaneously. Never saw it again though, so I guess it lost interest.
By this point I was a little low on health and decided to hop back down into the underground. Got as far as the snowy caves before things kinda went to shit, but they at least did so in a highly entertaining fashion...
Protip: Don't use whiskey against snipers. They become just as horribly inaccurate as everyone else (except the lobber jetpackers, who don't seem particularly bothered by the debuff) which, while immensely entertaining, also means they can inadvertently lead you by virtue of randomly shooting a little too high/low. Ended up getting pinged by a sniper shot that went through my shield while I was a good 20 degrees off from where the laser had been pointing.
E2: Also daily (or just random) form runs would probably be pretty great. Have your base form for that game be some random critter.
The problem with this is just how INCREDIBLY GODDAMN SLOW some of the mobs are, and also how many of them can't use their attacks properly when player controlled.
As far as perma-poly goes, yeah... I think we both know why that would be pretty broken.
In other news, I've got a hypothesis I want to test out... So, if you're holding an empty flask while standing in a mist spell, the bottle will fill up with the mist fluid, even though it doesn't collect on the ground. I've noticed that the circle of vigour spell seems to have the same colors and sound effects as the lively concoction, so I'm wondering if that's actually how it performs its task. LC is apparently stable when bottled, so if you could capture even just a little bit while standing in the field, you might be able to squeeze a few more drops of use out of the spell... If that's even what's happening, of course.