I've been a user of Dwarf Fortress for a very long time at this point. I wasn't around for 2D, but I was around since version 27 or 28. I also would miss all the old keyboard support, but at the same time, I have played Rimworld, Prison Architect, and other similar games that, while I wouldn't call them clones, are obviously heavily inspired by Dwarf Fortress and wouldn't exist in their current states otherwise.
I think one of the reasons those games are so easily doable with a mouse is because theyre simpler and smaller. Theres only one Zlevel in those games, so they never had to solve how to dig out a 100 Z level stair well to the magma layer. They never need to compensate for people who draw huge layer sized mining operations where the entire layer is criss-crossing tunnels. They dont need to suddenly construct 50 bedrooms. But they do have compensatory controls to make their own limited options easy. For example, if you build a bedroom in rimworld and have it set up how you want, you can use the copy and paste tool to drop five more right next to it.
Does the premium version have tools like this? For example, if I can designate a bedroom, then copy and paste it a few times, then that will be faster than even the keyboard controls currently are. Once they are dug out, can I then place all the room's furniture I need, then copy and paste those into the other bedrooms? I don't want you to actually just become a clone of other games, but all these other games have these Quality of Life features for a reason.