We must spread life as we know it, because that's the only one we are sure exists. And we should do it aggressively as long we don't find any other life
Must we? Sure, it seems like a good idea from our perspective, but we can't just assume that's some objectively true universal good. Also, if the universe is doomed to some sort of death anyway, it's ultimately a futile gesture, like prolonging palliative care as long as possible.
The planet Earth can support maybe 10-20 billion humans if we really tried. Sure, we could have "more people" if we live in space, but what's ultimately the point of having more people at once? The more rapidly we expand, the more resources we consume, and the less efficiently we do so.
Pretty much whatever changes we make will increase entropy, and thus speed up the heat death of the universe, reducing the total carrying capacity of the universe (across it's lifespan) for sentience. In terms of added entropy, seeding life on other planets and waiting for sentience to arrive is inefficient, but also playing God in a cruel way. You have to own all the suffering you're going to create along with the joy.
However, we might in the future be able to model sentience, and we could do that in a way that minimizes the rise in entropy per "unit" of sentience (however it could be measured), and also doesn't create inadvertent suffering. Seeding a few suitable planets here and there with life might make sense in a "nature reserve" sort of way, but it's not the main game. The longterm main game is space-based computational arrays that draw energy straight from sunlight.