That's why a lot of pages ago I suggested the only practical way to travel to other stars with foreseeable/feasible technology is dramatically extend our life span or send really advanced robots.
If we could live 200 or 300 years or more then a 50 years travel wouldn't be as much burden, because despite still being an awful chunk of someone's life it wouldn't be ALL of it. Someone preparing 50/100 years for such mission, going there and back using 100 years and then living here as an hero for yet another 50/100 years doesn't so bad in comparison to traveling there to die.
Of course all this are conjectures and then there's the issue of how to extend human life two or three fold, if it's even possible at all. Just that I think it could be sightly more probable that finding a way to build a feasible warp engine or something.
The other option would be triggering really extensive hibernation on humans. Sleeper ships.
On colonies I already stated my mandate, to the moon first! Hehehe... I think the moon if far more easy for a number of reasons. Relative closeness to Earth, "easy" colony setup by remote controlled machines, virtually no communication lag (I get more lag on whatsapp phone calls than what theoretically a radio call would get to the moon).
But first things first. All those people whinging about "nuking space", "nuclear contamination of space" and such, should be strapped on a rocked and exposed to the vacuum they "want to save and keep clean of radiation" (yes I heard that first hand) and then the survivors rounded to work as indentured workers on uranium mines....