I set up a deck with an opening hand that was always the same due to the innate mechanic: boot sequence (free 10 block, with the anchor relic I had 20), storm+ x2 (each time you play a power, channel 1 lightning), defragment+ (3 focus making lightning more powerful, made innate with the bottled tornado relic), hello world+ (gain a random common card every turn)*. This deck also contained static discharge+ (channel 2 lightning on taking attack damage) and electrodynamics+ (lightning hits all enemies, channel 3 lightning). All of the above except boot sequence are power cards, meaning for example electrodynamics actually channels 5 lightning. I also have many lightning channeling cards including tempest+ (cost x, channel x+1 lightning), fission+ (evoke all orbs, gain orb slots for each evoked that way) and I had multiple charge battery+ (blocks and gives you energy next turn) to make use of my faster drawing.
Needless to say if the final boss had been the Awakened One I might have been in trouble, especially since I had a relic that prevented me from seeing enemy intents. But it wasn't, it was Decu and Donu. I drew electrodynamics on the second turn and killed them both simultaneously; the whole fight was like 4-5 turns. Kinda thought power focused builds on the Defect were a trap but I guess with frozen egg in act 1 they're viable.
Slay the Spire. I'm on ascension 14, two more wins and I'll have essentially "beat the game" as Defect
*I've seen people on reddit saying this card is the worst ever because it pollutes your deck with bad cards. These people are what I like to call "wrong". If you run it with a huge deck you'll never shuffle, so its basically +1 draw that can't be a status and doesn't cycle your deck faster making you further resistant to statuses.