My issues are roughly the same Shonai_Dweller mentioned.
- Family & Friends (and sometimes "make romance") needed, but the have no drive to get either.
- Food badly broken due massive unavailability further compounded by extremely specialized requirements in many cases. Either the system would need to revamped so a sealed fortress can still get a reasonable match, possibly requiring some standard embark purchases, or the negative impacts should be reduced such that they'd basically get happy when they get their things, but won't be massively unhappy if they can't (unless the personality is extreme, of course).
- When given time off, they still won't satisfy badly distracting needs (often praying), but rather keep returning to satisfied ones, such as Socializing (with irrelevant people, of course), and I've seen the same with people who just won't go to the library where they're assigned a scholar position to fulfill badly distracting needs, but, again, keep Socializing or praying to gods they've already fulfilled their needs with. You could, of course, say that it reflects real humans, who keep doing things that they know are bad for them and avoid ones that are good, but this isn't The Sims where you need to babysit one critter...