@Robsoie
I was thinking that adventures would still be planned, like your average tabletop. There are just some things that humans aren't as good as computers at, and effortless world-gen is one of them. I would likely initially gen it in DF or one of the
@Xyon
I like the simplicity and open creativity of BoL's health, magic, and armor system. Aspects of it look like good candidates to adapt to DF. From what I've read, warhammer fantasy's hp and career system are a good fit. For sanity/corruption, I think that the One Ring LOTR system is the best I've seen - it's very narrative and tailored to each character.
I'm almost tempted to try and scavenge together a system, but I've got no experience. Might be a fun project though. The biggest challenge would be have to balance the specificity of DF with open world, the gritty realism of it, and the fact that magic has yes to be defined. There'd have to be a system for making monsters on the fly as well, seeing as there are a billion different [insertanimal]-men in DF. Character gen would have to be somewhat random, like 1E DND, but also streamlined because likely you'll be dying quite a bit. You make your character based around your stats, not vice versa. Elves would be shit in melee. Not all races would be able to play together, etc. Maybe a mechanic for the sheer randomness, like the destiny mechanic from Edge of the Empire? Dice could also easily be a pool or simple pass/succeed.
Some things to peak at
http://cubicle7.co.uk/our-games/the-one-ring/the-one-ring-game-system/http://khorne.ru/2nd/wfrp_web/Core.pdfThe more I talk, the more I actually might have a go at this, honestly.