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[martinuzz]

I've found weed (THC) to be the best self-medication for dampening my overstimulation.
But only like, one joint per day / 2 days.

Smoking weed all day every day makes me a couch potato which is not what I am looking for.

[Il Palazzo]

The doctors saved his life pretty easily after that by giving loads of powerful anti-fungals, thus stopping the creation of the world's first plump helmet man

They saved a life, but they killed a dream.

[scriver]

I sure as fuck hope the fuck they never will. Thst would be even worse than the current depression med situation

The situation I meant being that they just give you meds and shunt you off like they do now

I wasn't very clear on that

[dragdeler]

I'm not too worried about that, the stigma is still gigantic and the red tape thusly proportional. I'm actually surprised the few promising studies are so well known (and accepted) around the forum, because it's a muddy subject. Psilos are not antidepressants per se, well with the possible exception of hawaians which used to be advertised as containing actual serotonine in the smartshop, which I'm both dubious that they did, and that is could be meaningfully absorbed through the stomach...

Mushrooms would be a tool for therapy sessions, either by multiple microdosed sessions, that'd barely cross the treshold to psychoactive, to harness the very mild boundary dissolution into more openess, or either by going hard and having a life altering experience which I don't see many therapist have the courage to do. I can see mdma being more effective during the session, eventhough it has detrimental effects on the serotonine budget, which beings me to the economic aspect:


Mushrooms are too easy to produce... I could totally see them adopt mdma, so pharma can profit, the effects are less durable and the people go back more often to their therapist.





BTW vector: what you take seems very use appropriate, cbd is a thc antagonist, and can take the edge of psychedelic effects. If avoiding panic attacks at 2am is the biggest priority stay with that, don't try to smoke potent sideproducts (skuff, pollen, ice'olator) or concentrates deep within the night.

[Vector]

The reason why I know about the shroom experiments is because for the past five years or so, when I tell people about my symptoms they tell me to hold on cuz the psychedelics are on the way. They say it in kind of a similar way to "don't worry! I hear the cavalry! They're just over the hill!" The early research, to me, looks really promising, especially given the other options I've been presented with: we have almost no PTSD-specific medical treatments and a lot of medication manufacturers trying to claim that their pills "might" be helpful for trauma and therefore "should" be given to patients.

I don't think it will fix everything, but given that the treatment is supervised microdosing with therapy, I could see therapists in clinical practice getting certified in that. I'd personally feel a whole lot better about being treated by a therapist than by a doctor given how fucking hard my therapists generally have to work. They have a deeply vested personal interest in doing a good job and being successful, and are usually losing a lot of money on me (like $80/session) because they give me the "pro bono" rate.


@dragdeler: yeah, I'm sure because I'm familiar with my overall personality that I'll try actually smoking the stuff at some point, but when I went in to buy things I made sure I had gotten medical products only (low-dose edibles with very little THC). Even that sparked some brief panic attacks but nothing much worse than normal intrusive thoughts... which is how I intend to keep it

[nenjin]

Just don't be like that absolute maverick who injected a boiled mushroom solution into his veins. Two days later he was suffering from organ failure and doctors couldn't figure out what was wrong until they clocked that the mushrooms were alive and growing in his blood

The doctors saved his life pretty easily after that by giving loads of powerful anti-fungals, thus stopping the creation of the world's first plump helmet man

Jesus. Sounds like nightmare fuel, and not dissimilar to a nightmare I had last night about a guy sitting on a couch and turning into a fungus man.

And yeah, as far as weed goes, it affects everyone differently. It's a psychoactive substance so there's no real telling how it interacts with your own brain chemistry. For some people, it's a release. It turns the volume knob down on their brain. For others, it puts them in overdrive and results in paranoia.

I do wonder though for the paranoia people how much of that is instigated by their knowledge of how society perceives it.

[EuchreJack]

Note: This thread has hit 666, so Nightmare Fuel is now required until the thread hits the next page.
This is a joke, and not an entry into something that will make people upset. Thank you.

[dragdeler]

That story was wild... I don't even know what his plan was because some tryptamines are rumored to be less effective IV... Can somebody tell me: is it true that smoking crosses the blood brain barrier easier than IV (in some cases?) and if so why?



Fair enough vec, but if you're freezing and shaking don't tell me I didn't warn you ^^ I used to collect the "pollen" (trichnomes) over the day, to really knock myself out before sleep, I still like it, but I must admit that period was when I had most often had to wrap myself in 3 blankets and get a hold on my breathing. I don't mind, but I stopped bothering with all the micromanagement necessary to harvest the pollen.

[ChairmanPoo]

https://www.sciencedirect.com/science/article/pii/S266729602030015X#

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Journal of the Academy of Consultation-Liaison Psychiatry
Volume 62, Issue 3, May–June 2021, Pages 370-371
Letter to the Editor: Brief Case Report
A “Trip” to the Intensive Care Unit: An Intravenous Injection of Psilocybin
Author links open overlay panelNicholas B.GiancolaB.A.Curtis A.McKnightM.D.
https://doi.org/10.1016/j.jaclp.2020.12.012
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INTRODUCTION
TO THE EDITOR: Psychoactive fungi, colloquially known as “magic mushrooms,” are known for their hallucinogenic properties mediated by psilocybin, a tryptamine-like alkaloid metabolized to the active constituent psilocin, a 5-HT2A receptor agonist.1 While usually taken orally, there are anecdotal reports on the Internet of the recreational injection of psilocybin, though the professional literature on this practice is scant.2,3 Here, we describe a case of a 30-year-old man who injected psilocybin intravenously resulting in an extended stay in the intensive care unit because of multiple-system organ failure.

Case
Mr. X was a 30-year-old man with bipolar disorder type I and a history of intravenous drug use admitted to the hospital after being brought to the emergency department by his family concerned that he was confused.

History gathered from his family was remarkable for recent nonadherence with his prescribed psychotropics (risperidone and valproate) and subsequent cycling between depressive and manic states. He had reportedly been researching ways to self-treat his opioid dependence and depression.

In his reading, he encountered reports of therapeutic effects of microdosing lysergic acid diethylamide and hallucinogenic psilocybin mushrooms prompting him to inject what he had named “mushroom tea” – psilocybin mushrooms boiled down in water. He then “filtered” this substance by drawing it through a cotton swab before directly injecting the solution intravenously. Over the next several days, he developed lethargy, jaundice, diarrhea, nausea, and hematemesis before he was found by his family and taken to the emergency department.

Initial examination was remarkable for O2 saturation on room air of 92%, heart rate of 100, and blood pressure of 75/47. He was noted to be ill-appearing with dry mucous membranes, mild cyanosis of the lips and nail beds, and jaundiced skin. His abdomen was diffusely tender to palpation without rebound or guarding. He was grossly confused and unable to meaningfully participate in an interview.

Laboratory studies revealed thrombocytopenia, hyponatremia, hyperkalemia, hypochloremia, hypocalcemia, acute renal insufficiency, and acute liver injury. Cardiac workup revealed elevated cardiac enzymes, and his electrocardiogram was remarkable for sinus tachycardia and early repolarization. He was then transferred to the intensive care unit for evidence of multiorgan failure, and he was started on intravenous fluids, multiple vasopressors, broad spectrum antibiotics, and antifungal medications. His hospital course was further complicated by septic shock and acute respiratory failure requiring intubation on hospital day 2 and disseminated intravascular coagulation requiring plasmapheresis. Cultures confirmed both bacterial (ultimately cultured as Brevibacillus) and fungal (ultimately cultured and DNA identified by a specialist laboratory as Psilocybe cubensis – i.e., the species of mushroom he had injected was now growing from his blood) infections. He was treated for a total of 22 days in the hospital with 8 of them in the intensive care unit. At the time of writing, he is currently still being treated with a long-term regimen of daptomycin, meropenem, and voriconazole.

DISCUSSION
While it is evident that he was harmed through his use of psilocybin, current investigations of its therapeutic potential as an adjunct to psychotherapy in treating a variety of psychiatric conditions – including obsessive compulsive disorder, substance abuse disorder, anxiety, and depression – have been documented.4,5 The case reported previously underscores the need for ongoing public education regarding the dangers attendant to the use of this, and other drugs, in ways other than they are prescribed. It is unclear whether infection with a psychoactive fungus such as P. cubensis may prompt persistent psychoactive effects as seen with ingestion of the same species which could further contribute to changes in perception and cognition.

References
1
F. Tylš, T. Páleníček, J. Horáček
Psilocybin – summary of knowledge and new perspectives
Eur Neuropsychopharmacol, 24 (2014), pp. 342-356
ArticleDownload PDFView Record in ScopusGoogle Scholar
2
J. van Amsterdam, A. Opperhuizen, W. van den Brink
Harm potential of magic mushroom use: a review
Regul Toxicol Pharmacol, 59 (2011), pp. 423-429
Google Scholar
3
S.C. Curry, M.C. Rose
Intravenous mushroom poisoning
Ann Emerg Med, 14 (1985), pp. 900-902
ArticleDownload PDFView Record in ScopusGoogle Scholar
4
M.W. Johnson, R.R. Griffiths
Potential therapeutic effects of psilocybin
Neurotherapeutics, 14 (2017), pp. 734-740
 View PDFCrossRefView Record in ScopusGoogle Scholar
5
R. Carhart-Harris, R. Leech, T. Williams, et al.
Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin
Br J Psychiatry, 200 (2012), pp. 238-244
 View PDFCrossRefView Record in ScopusGoogle Scholar
Cited by (3)
Human behavioral pharmacology of psychedelics
2022, Advances in Pharmacology
Show abstract
Adverse experiences resulting in emergency medical treatment seeking following the use of magic mushrooms
2022, Journal of Psychopharmacology
Comment and Response: (Lugo-Radillo & Cortez-Lopez, 2020) Long-Term Amelioration of OCD Symptoms in a Patient with Chronic Consumption of Psilocybin-Containing Mushrooms
2022, Journal of Psychoactive Drugs
View Abstract
© 2021 Academy of Consultation-Liaison Psychiatry. Published by Elsevier Inc. All rights reserved.
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RELX group home page

I have questions about this case

- space reserved for an impromptu journal club

[ChairmanPoo]

- space reserved for an impromptu journal club

Some questions that arise, to me, from the case report:

- Was the patient HIV positive?

- Was there any imaging done? If so, what were the findings?



Thing is, in an immunocompetent person you wouldnt expect this sort of thing to happen. If he was immunocompromised the whole thing becomes clearer. It'd be consistent with the IV drug history.

I also find the wording of "ultimately confirmed". A bit odd. Would be nice to get more details on what the report said in the end. Would also be nice to know what radiology findings were there. Or histology findings for that matter. Ie: was any specific organ with a fungal infection identified?

[dragdeler]

Oh he did it because that's how he does everthying: he's a fixer.


Goes a long way of showing my reluctance tho, he fully accepted psilos as antidepressant medication. Nope it's a therapy tool.

[hector13]

Desperate people do desperate things. Throw in poor mental health, recipe for disaster.

[Loud Whispers]

the species of mushroom he had injected was now growing from his blood

Ahhh ah that's something I'll never not have to reread thrice

[Egan_BW]

Note: This thread has hit 666, so Nightmare Fuel is now required until the thread hits the next page.
This is a joke, and not an entry into something that will make people upset. Thank you.

Sorry it's page 200 in the true count.

[EuchreJack]

Texas State Rep. Bryan Slaton is trying to ban kids from going to a drag show at a bar. Note the definition of child is probably anyone under 18.

While that does piss me off, my main reason for posting is that several Texan Legislators seem to be admitting to going to drag shows. And apparently the things they're doing at the drag shows are Adult Themed.