Isn't FO4 meant to be Gameworks
Makes me kind of doubtful that this is specifically and exclusively an Nvidia problem.
It does seem to be happening with AMD cards, but people are more frequently reporting it with nvidia cards.
I had this error with my GTX 970 on various games over the course of the last year. The issue was that the card itself was failing, unfortunately; it almost seemed as if it ran out of memory, or the card itself crashed, as I only experienced it on certain high requirement games (Sins of a Solar Empire was good at this in particular, in the late game with a few hundred ships fighting at the same time). Thankfully I was able to get it RMA'd by EVGA, and I haven't had the issue since.
Yes, the problem with the TDR errors is that there are many ways that it could happen but without expensive diagnostic systems you can't troubleshoot them all. Could be bad drivers, bad motherboard, bad ram, bad video card hardware, bad PSU, overheating, faulty power connections, a dozen other things. The error itself tells you nothing and even the windows event viewer is completely unspecific.
I have had this crash before in another game, but it was months ago and I don't even remember what it was. Maybe Sacred 2 Gold? Which isn't even all that graphically intense. Whatever it was, it was very rare at the time, and extremely frequent in FO4, and is not repeated by other graphic intense games like Planetside 2. So my estimation is that it is something about FO4 specifically in how it interfaces with my overall computer setup and probably focused on the nvidia card, rather than bad hardware or an issue with performance settings (that is, my card isn't faulty, or overheating, or being taxed beyond its ability). Might be something Nvidia has to fix, might be something Bethesda has to fix, might be something the user himself might have to fix.
Just trying to get a broader cross section of people who may also be having the problem.
Edit: Actually, I think the last time I saw this was with Shadows of Mordor.