Humans had just began to explore and settle the reaches of space. They terraformed planets, assembled fleets, built great hulking cities in deep space and yet they remained as they always had. Governments rose and fell on the homeworld and colonies elsewhere, human factions went to war against eachother, and even against the races of other galactic civilisations which had found purchase in the stars. Humans developed a reputation as very fickle creatures, and it was not entirely undeserved. As the march of time moved inexorably forward, humanity lost track of itself. Not every human colony even remembered the existence of the homeworld, so far from it in time and space their people had travelled, some of these societies effectively disappeared from history.
One day though, ships began to appear in human space, ships that neither the human civilisations or their neighbors knew anything about. These ships came to be called the Pantheon. They hung dead, drifting in space, and of course human scientists soon became curious enough that they decided to crack one open and enter it. The attempt to breach the hull of one of these ships caused it to flare to life and quickly destroy the scientific vessels come to study it. From there it destroyed the entire human population of a nearby planet with an armament far superior to anything any human had ever seen before. It took the united forces of nearly all human governments to assemble a fleet up to the task of eliminating this threat.
The ship was neutralized, and immediately cannibalized for it's technology, though most of what was found there has remained a secret from you. Almost immediatly after the human victory however, every Pantheon ship humans had under surveillance activated, and continued where the first had left off. The crippled human fleets had no chance to defeat this foe, the only option was running.
Thankfully the secrets of Pantheon technology gave humanity a hope of accomplishing this. The ship that had been taken apart ran on a Reactor that human scientists didn't even understand, for it seemed to run on a power source that humans could neither detect or measure, but they could duplicate the Pantheon Reactor on a smaller scale all the same.
You are the head of a private corporation that helped to fund the war effort and the research of Pantheon technology. With the backing of grossly wealthy investors you commissioned a small fleet of ships powered in part by these reactors, and you've taken one of these ships for yourself, with it you intend to escape death by the Pantheon. With you come one hundred and eleven of the greatest minds in your system. The ship will be lightly armed, but with a variety of facilities that could greatly benefit the creation of a colony elsewhere including a Robotic machining workshop, a supercomputer AI intelligence, a self contained ecosystem capable of sustaining the ship's population for a century provided it doesn't grow, a deployable atmospheric dome complete with an apartment complex, and a databank full of more information than the entire crew could read in their whole life.
Soon one of the Pantheon ships will be arriving at the planet you call home, there is little doubt that it will make short work of the planetary defences, and then will bomb the populace into oblivion. You must make a choice, the Pantheon Reactor Engine that is the primary feature of your ship is powerful, but also poorly tested. Normally navigation is a simple matter of mathematics, but here it is guesswork, and so you cannot arrive at a location you specifically designate.
-If you go only a relatively short distance, perhaps just outside of the boundaries of previous human colonization you will be able to aim for an ideal location. You will know the area, and whatever neighbors you possess. Perhaps best of all, it is likely that fleeing humans would pass through your new territory frequently, giving you the opportunity to increase your strength. On the other hand, the Pantheon will still be nearby, and if they find you it could spell your doom.
-You could go a reasonably lengthy distance, to space that you've heard of but that few humans have been to before, close to alien civilisations you are familiar with, and still allowing for contact with human settlers, but far enough away from the Pantheon ships that you're not likely to see them unless you draw their attention somehow. Unfortunatly you may not initially find a suitable location for a settlement, but it's possible you could ask local alien civilisations for assistance.
-You could go into the far reaches of deep space, into territories no human being has ever explored before. You never know what you might find, but it would be next to impossible for the Pantheon to find you. Truth be told, you probably wouldn't have an easy time determining where you are either. You're unlikely to find human settlers, but any alien civilisations you encounter are unlikely to have heard of you, so you would be starting with a clean state, rather than a reputation for petty warfare and fickleness.
So where will you go to escape this menace?