Kinda curious about what game you mean. I haven't been playing much new stuff, but I have been playing UFO:Afterlight. The UFO series sooorta has that, except that like XCOM (new and old), when you finish the tech tree you're pretty much done.
I don't mind games that just have a research UI that doesn't require any special infrastructure or skill, because in the end the research screen just goes away (or in many of those strategy Sid Meier's games you just keep either doing "miniaturization" or even in the old Civ games just added to your score with no in-game effect). It's more noticeable in indie games, but XCOM also has that to some extent (I don't remember if you have any use for scientists afterwards, but anyway that game has an ending and if you've exhausted your research you're probably close to winning anyway). If there wasn't any benefit in Civ-clones, you could sell all your libraries, I guess? Unless they give happiness boosts or something.
A few examples I can think, indie-wise: Oxygen not Included, Rimworld, Starship Theory. You have to actually build and train people in Research, which becomes completely useless afterwards. And might as well deconstruct the research tables because they don't do anything, but they made your base look cool maybe, and now they just sit there... so the choice is leave them as decoration or just repurpose them or whatever... for "roleplaying" purposes it's a bit weird a bunch of scientists going "well... we learned everything possible, let's just stop."