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[Sheb]

As far as I know, they broke down the genomes into pieces and sequenced them, so one part of the genome comes from one guy, one part from another (70% of the reference genome apparently come from one donor in Buffalo). Polymorphisms weren't really studied during the Human Genome Project.

[MonkeyHead]

This thing I'm working on presently requires a method, which is fine.

Later on it calls for a justified method. Any clue what it means? Because I have absolutely no clue, and google's proving useless (as per usual when I ask here)

If this is in a scientific concept, it basically means offering up a reason for why you have chosen your method, I assume... *shrug*

[scrdest]

As far as I know, they broke down the genomes into pieces and sequenced them, so one part of the genome comes from one guy, one part from another (70% of the reference genome apparently come from one donor in Buffalo). Polymorphisms weren't really studied during the Human Genome Project.

That doesn't quite follow. You must break a single human genome into parts to sequence it - it's too big otherwise. But it's not like they just threw together the sequences; the end result is basically an average of several sequences rather than a bunch glued together.

[Sheb]

As far as I know, they broke down the genomes into pieces and sequenced them, so one part of the genome comes from one guy, one part from another (70% of the reference genome apparently come from one donor in Buffalo). Polymorphisms weren't really studied during the Human Genome Project.

That doesn't quite follow. You must break a single human genome into parts to sequence it - it's too big otherwise. But it's not like they just threw together the sequences; the end result is basically an average of several sequences rather than a bunch glued together.

Is it? I'm not sure they actually had multiple coverage for all parts of the genome.

[scrdest]

I wanted to fact-check, but Nature was down due to some technical issues. There is at least *some* overlap, due to how the assembly process worked. And I don't see why there wouldn't, it's not like the DNA itself was scarce, and doing that would reduce the chances of ambiguous results popping up. And I found that there was a difference in coverage between 'draft' and 'final' published sequences.

And either way, Celera ran its own project in parallel, so there's at least one overlapping result to analyze.

[Neonivek]

Ok here is a question nearly impossible to find an answer for.

Why when Semi-automatic guns were coming out were people so resistant to the idea of them often sticking to non-automatic?

With Cars I sort of understand it is an entirely new system and technically manual isn't better then automatic.

Yet with semi-automatic versus non-automatic the only real difference is how often you can pull the trigger.

[sprinkled chariot]

Ok here is a question nearly impossible to find an answer for.

Why when Semi-automatic guns were coming out were people so resistant to the idea of them often sticking to non-automatic?

With Cars I sort of understand it is an entirely new system and technically manual isn't better then automatic.

Yet with semi-automatic versus non-automatic the only real difference is how often you can pull the trigger.

Well, there is sort of anecdote about Fedorov coming to imperial russian army generals with project of autorifle only to get response : "" Where will we find enough ammo for this? "
Probably, this may be one of reasons.

[Sheb]

Might have different names in different field, but in biology we call that a spectrophotometer.

[Comrade P.]

Why when Semi-automatic guns were coming out were people so resistant to the idea of them often sticking to non-automatic?

The military is quite reluctant to embrace new technology. In particular case of semi-auto versus bolt action, which was sort of common before that, man, you should see the early semiautos, they were a mess. The few examples we know to be successful today were mostly embraced due to marketing successes of businesses.

At least that's the impression I get.
May I refer you to this channel for aforementioned early semiauto rifles and many more oddities of the realm of small arms.

[MonkeyHead]

Ok here is a question nearly impossible to find an answer for.

Why when Semi-automatic guns were coming out were people so resistant to the idea of them often sticking to non-automatic?

With Cars I sort of understand it is an entirely new system and technically manual isn't better then automatic.

Yet with semi-automatic versus non-automatic the only real difference is how often you can pull the trigger.

Combat doctrine and training would play a big role here. WW1ish, Armies were set up around the concept of squads of riflemen laying down precise(ish) fire. Semi-auto might help rate of fire, but potentially at the cost of accuracy and at great expense. Hand held (semi) automatic firearms played specialist roles (German Stormtroopers and assorted trenchbrooms...), but general infantry tactics revolved around rifle fire from range while advancing, not close combat "fire and move" mobility. It took WW2 to really shift that manner of thinking, with the M1 being a semi automatic rifle used in the same way as bolt action rifles, in general. Remember that military forces are led by Generals who learnt to fight the generation before the one they lead in combat.

[Erkki]

Bolt actions tend to be more accurate, cheaper, lighter and more reliable(fewer moving parts, fewer parts that need to resist high temperatures and pressures), especially back then.

Nowadays bolt actions still are more accurate, albeit the difference is becoming ever smaller, and(for special uses) they can be silenced\suppressed better. Many armies still regularly use bolt-action rifles, because they're useful.

I think most of the accuracy difference comes from bolt-action rifles' barrels being possible to free-float all the way from the chamber, while gas-operates semi autos need the gas tube for the action to work.

edit: also tolerances. The chamber can be made tighter when its known that the gun wont heat up much and will fire just quality ammo with known dimensions and qualities. Someone more knowledgeable can hopefully tell more!

[Tawa]

Can anyone access this site?

[Wolfhunter107]

Can anyone access this site?

I can. You having issues with it?

[Tawa]

Yeah. Dunno why, I guess I'll just wait.

[Rolan7]

I want to know why there are fireworks happening tonight (Asheville NC, USA, that's no secret now).
You'd think that'd be easy to look up, but there were about 3 firework events last year which I couldn't find any explanation for.
Not counting 4th of July, obviously.  And the other events didn't seem to land on important holidays.

Godsfucked Fathers Day isn't until Sunday anyway I think