You don't have to go for heavy artillery to find antibiotics that target both. You pointed one out yourself in your example (cephalosporins). In fact, the most commonly used antibiotics do, in fact, target both Gram + and - bacteria.
Uh, what exactly are you responding to? I never said wide-spectrums don't real, I just pointed out that narrow-spectrum antibiotics exist, and so natural antibiotic producers don't necessarily
need to be resistant.
the very first antibiotic being fungal
Arsphenamine and the sulfonamides beg to differ.
Fair enough, I didn't specify what rules I was going by: Protonsil was discovered in 1932, so later than Penicillin, though it was marketed earlier, so by actual availability it has primacy. Arsphenamine is not usually counted as an antibiotic for, upon some research, weird reasons.
Sure, I said most, not all. Wiki tells me that 2/3rd of all natural antibiotics used come from Streptomyces. As for the b-lactams, they're fungal, but the resistance was already out there in bacterias before we used them. The resistants bacterias didn't invent a new hydrolase, they just made use of what was already there.
And even if they're semi-synthetic, they're still close enough to wild-type antibiotics that it's not much work for existing enzymes that degrade the wild-type antibiotic to evolve to be able to degrade the variant. See, cephalosporins and all other b-lactams derivatives.
I mean, no offense but I'm kinda doing my PhD on carbapenemases.
All the more reason to try to argue then, better me than the reviewer
I didn't actually know there was a resistance in the wild, how do we know that's the case? And one way or another, unless you're somehow both a bio grad and creationist I suppose, they did invent a new hydrolase, the only question is when.
Unless I massively misremembered, I think you're wrong on the topic of (semi-)synthetics. I recall watching a video on topic of antibiotic resistance (I think it was a part of an intro to a vid about teixobactin maybe) that showed the arms race between beta-lactamases and beta-lactam modifications preventing lactamase cleavage of the ring. But unfortunately that was shown in class, like two years ago, so I might be spectacularly wrong here. I didn't research it just now, I'll check later.