I'll discuss some ideas for lack of anything better to do!
Idea I
I've been playing around with an old idea (that I fully got in a pretty cool dream). Basically, after some great cataclysm humanity lives on floatung islands governed by a nobility of superpowered individuals, each fighting for power, intermarrying, repressing the mundane population and whatnot, as noble houses do. A big part was trying to breed specific powers through dynastic marriages.
Anyway, that's just the setting, but I've been considering a strategical dynasty control game, where the players would handle their entire House, perhaps through the eyes of the current 'head' of the dynasty. Possibly the years would move quickly, the head of the dynasty changing.
I could also go for an RPG or suggestion game, tbh. This be little more than a setting.
Idea II
The Primordial Bloodlines. Basically, the players would head werewolf clans, vampire bloodlines, mage orders, fallen angel cults, etc. from the dawn of the world to, eventually, an urban fantasy modern-day world. Their choices and teachings would shape their followers/descendants (such as absorbing an animal spirit and your descendants gaining its powers in weaker and weaker form). Their petty grievances and alliances might continue in others for hundreds of years.
Eventually, the world that would have emerged could be used for a more traditional form like an RPG. The old ancestors might even cameo, depending on their fates.
The problem here would be keeping in the personal level. I'd probably just include miniquests with limited a), b), c) progression alongside the general strategy play and orders.
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I also have the strangest urge to run a Godhood-esque god game. Nobody sane would want to do such a thing, but I dunno. My best forum writing is born in these games already, might as well go for the GM's seat.