Right now I'm doing Easy mode to re-unlock all my ships. I usually play on Normal, though. Haven't tried Hard yet, but I imagine I'll do that once I'm doing with all the unlocks, just to see how it is. Normal mode is probably where I'll stay, though. Easy is generally too easy for me, although if I'm a little careless or really unlucky I can still lose.
Lost my last run, actually. Going with Redtail and had a great weapons set-up. A Chain laser, Vulcan laser, and two basic lasers. Chewed through enemy shields like no one's business and made it very easy to go through most fights. Could not for the life of me get any defense drones, though, which cost me at the very end despite my Cloaking. Enemy MC'd my door controller who proceeded to smash them to bits with the help of a boarders. Then my cloaking room got set on fire and I couldn't get to it in time since all my crew was busy fighting off boarders, and I couldn't vent because the doors were out. Cue the next super-weapon shot taking out my weapons and shields while fires broke out everywhere from the enemy drone blasting me.
If I'd been just a bit faster with a few things I probably could have salvaged it but I wasn't giving the game 100% attention because my fiance kept asking me questions about wedding stuff. *sigh* I should know better than to try to do boss fights when I might get distracted.
Wasn't a waste, though. I unlocked the Kestral C, the Rock Cruiser, and the Lineus ship on that run.