Just had a nasty death. Game was only going okay, playing as the Torus, had plenty of Engi crew and a Zoltan, but no combat-oriented personnel.
Jumped into a solar flare region. That would be bad enough, but I was also boarded by 4(!) Mantis, which required constantly rotating crew through the medical bay (because even with the medical nano augment, there was no real way for an almost-entirely Engi crew to take on four Mantis). I ended up jumping with half the ship O2-less and a few fires that I was hoping to go out.
Surprise! Mantis ship, which immediately teleports over a boarding party which begins wreaking havoc. They take the weapons out almost first, while rapid-fire heavy lasers and what I assume was a Hermes missile destroy the medical bay, the doors, and the drone control, creating a hull breach at the same time. Keep in mind that a good third of the ship was still airless after the solar flares at this point. With the doors gone, I couldn't even close the airlocks or open doors to route what little air remained into vital areas.
Still, I pressed on. Engi and the Zoltan ran all over the place attempting to keep systems operational, while the human stayed at the helm; my only hope was to somehow dodge the missiles and lasers. It was a futile effort though, since just about every attack, especially the missiles, hit. What's more, every single hit either created a breach or damaged a system. I used four drone parts due to having to constantly reactivate my attack drone, the O2 room got breached not once but twice, and the medical bay got hit early on and was one of those rooms devoid of air.
In the end, it wasn't hull damage that killed me. Between battling the boarding party (which never actually left) and taking hits from uncannily accurate enemy fire, my entire crew perished one by one.