Endured base defense while three of my best soldiers where having their heads looked at to see if they could kill with their minds.
I'm pretty sure the trigger for base defense is building your psi labs, so you really shouldn't shove your best soldiers in right away if your worried about it all.
On a another note.... I'm disappointed. There was that whole article ranting about how Impossible was made even more impossible, but my current II game is disappointingly easy >.>. Sure had some rough spots early on, and I realize the late game was never as hard, but in my II games in Unknown I still had a challenge in the late game. Now, between my two col. mechs and my mimetic skin scout everything is just kinda getting wasted. I don't have to worry about actually using decent terrain because they will always choose to attack my mechs over my people in shitty terrain, even though they can't possibly kill either of my mechs in less then 4 shots and in many situations easily flank and kill other members. With the retarded amount of explosives I get I barely even have to chance not doing full damage or missing. Oh, and while the Exalt missions are fun, over the course of two ironman games I have had 0 casualties facing them and seen them launch a total of one rocket.
The only death I've had in the past ~30 missions was one where I had a team with 4 squaddies and one of my mechs, and it happened to be the first time heavy floaters showed up.
(Though I partially blame actually doing Slingshot for the second time in like 15 games)