It sounds as if the only concern with a 16 x 16 embark, were it possible, is FPS death. Ever faster hardware will keep pushing FPS death back, as well as playing so as to keep the mobile count down. FPS death 'of a sort' is also a problem for Civilization, including Civ V: you have to wait for the other Civs to 'take their turn'. So at some point you decide to cut back on the number of Civs and size of your world to make playing the game tolerable.
But if you have a $2000 'game machine' or a cheap used Sun Blackbox emulating Windows, it ain't braggin' if you can swing it.
Civ V does not bother attempting to stop you from playing 'max size world + max size civs'. It certainly doesn't CTD when you attempt to do so. It simply has you wait while the many other Civs are plotting your death behind your back. Some sort of 'test mode' in DF wouldn't hurt.
"Run System Test" could be a new menu option. The system test returns a recommended 'max setting' and offers to write that max setting into your system's config file. The system test simply has a stock fortress and it spends a minute running that fortress from a known start point. A group of dwarves are committed to battle, foes are ready to destroy them. Other dwarves have tasks assigned to them, and the test runs for, say, 500 frames and then ends. The system can then figure out a 'score' for your system, and based on that score suggest you can run a 16 x 16 embark (after ensuring you have the memory to support it, and DF won't just CTD on you) or it may suggest you are pushing it if you do more than a 4 x 4 embark.
That would be a means to provide the game player a tool to evaluate how best to plan their DF gameplay experience without the CTD being a part of that.
Who would want to have a 16 x 16 embark? Well... if I have the hardware and the memory to support it, why not? Well, FPS death. Yeah? Well... what tools do I have to evaluate how big I can make it without FPS death in an established fortress? Crash-To-Desktop. Oh yeah, if you get a CTD, your fortress is 'likely' too big. K'thanks.
CTD is
NOT a reasonable means to suggest you are biting off more than you can chew on an embark. A 'standardized test run process returning useful info' would be far more useful than CTD. Hrm... 'standardized test run package' would be another suggestion I ought to post...