Unless said wires can't be coated because of their function or a need to use as little physical space as possible.
My experience of this is using a capping layer of gold over the top of any exposed circuits. Of course, this was using iron compound wires (FeNi permalloy or Fe
3O
4 magnetite) built on top of wafers for lab and imaging purposes. Working with commercial designs it's easier to close the whole system. Especially when you are talking about such a small system as in a computers processor or similar. Even if you did go with capping layers, the thickness would be negligible (a few atoms).
As for optical computing or any other form, I doubt any will catch up in the next decade. The latest chip architecture uses a 22nm transistor, with 14 and 10nm versions on the near horizon. For computation, size is speed. Until you hit some threshold (I'd guess for electric transistors it would be around 5nm or so, but potentially anywhere under 10nm) when things stop working right, smaller is better.
There just aren't any realistic competitors for this yet.I don't see any demands from computing that would make space resources a sensible goal. Then again, I don't see any earth based commercial or industrial interests that would. Lunar resources would make sense for a moon based industry, which makes marginally more sense than an earth based one. But then, once you are outside the local gravity wells you may as well stay there.