Compromise/Efficiency/Effective Government
-Easier said then done. Really, what is it about americans that makes them think that running a government is easy despite all the evidence to the contrary?
Nuclear Power
-Republicans support this, democrats only support it if it's part of a broader energy package, look at the senate debates from 2009
Gun regulation/freedom
-The median republican is strongly pro gun, the median democrat strongly pro-regulation, just because the members at the edge of the coalitions hold views at the edge doesn't change that
Education Reform
-Both parties have very elaborate agendas on this very issue
Foreign Interventionism/Isolationism
-This is too complicated to be a single issue. Look at the single issues inside it, like Iraq withdrawal or Libyan intervention.
Drugs
-Like I said, the exception but even so, the left is more drug friendly
Space Programs
-A pretty small part of the government and I am not aware of ANY voters who use this as a major issue. And believe me when I say that I have talked to LOTS of voters about politics
Anti-corporate/trust-busting policies
-Seriously? Here's a hint, the GOP will destroy the country before they fight the rights of rich people to get richer. They have spent 30 years systematically undermining unionization and any sort of corporate regulation. They have waged a war on science in order to foster an anti-regulatory movement. You are asleep if you can't call this one.
Agricultural support
-This is written into the constitution with the Senate/House compromise. Third parties ain't gonna change that.
But ignore all that - you know what one issue I'd like to see a party run on?
Doing shit that works, regardless of which end of the bullshit ideology one sits on. Neither party has shown any interesting in empirical, outcome-based governing. It's all about their fucking toddler-level ideologies.
And there we go with the perennial call of the non-partisan. If only a non-partisan were in office they would just use the mystical powers of impartiality to git'er done! But thank you oh so much for calling me a toddler for actually knowing what the parties stand for and basing my opinions on that.