Don't remember if I posted about this idea before, but here it goes anyway.
Wasteland Outpost Simulator: The Game (which you've just lost btw)
General outline, some sort of post-apo or wasteland or generally unpleasant world is the setting. Could be fantasy, could be Sci-fi, could be neither. After some years of adventuring, working as a no-name nobody, being a gun for hire, trading, or whatever you pick (I'm guessing it would give you a bonus or something like that, depending on your choice), you took an arrow/gunshot/laser blast to the knee and decided that it was about time you went after your lifelong dream of owning a tavern in the middle of nowhere. So you took your savings and you bought some stuff and you embarked to one of the many middles of nowhere that are ever so abundant in your world (again, choice of location affects the game in some way).
You start off simple enough, offering drinks and food and perhaps shelter to weary travelers and adventurers, building up your reputation as a generally not shitty place. Over time though your fame will attract other buisnessowners to your area, or folks looking for work, or folks looking for trouble. So the game shifts from managing just your place of rest and fun to managing certain bits of the now growing little town, as well as coordinating its defense against bandits/monsters/ailens/whatever is dangerous and wants something you have.
General progression would go:
-Small buisness managing supplies, beds and employees while trying to expand and become better known
-Large buisness managing employees, expansion of the tavern and the area while trying to become even better known and managing the now available job board (looking for rumors, striking deals with traders to take protection at your place, that kind of stuff)
-Small town managing your buisness and somewhat influencing the newcomers (so no direct control over other shops but you can perhaps steer them in a general direction that would benefit the town, you or both of you even) while coordinating defense against light attacks and trying to attract more folks/buisness to the town.
-Large town trying to keep everyone from not killing each other (did I mention factions would play a role? yeah, you'll need to play the diplomatic game after a certain point), keeping the buisnesses operating smoothly (coordinating supply caravans and perhaps expansions into new areas like production or something like that) and defending the town from larger attacks.
Buisness managment could be done from a top down or isometric view, either is fine. Lots of windows for info and whatnot. Defense would be also top down or isometric, a mix of TD and pausable real time tactics game like say Pillars of Eternity or something.
Well, that turned out way more text than I anticipated, hopefully it's not too wall-o-texty for you folks.