As far as XCOM goes I was playing that and Wasteland 2 at about the same time a while back and I was struck by how well the X-Com style structure fits the general Wasteland 2 concept. So: a Wasteland game where you send patrols of Desert Rangers out to deal with this crisis and that one out in the wastes, or just to scout, and also to get materials/ items/ workers to help establish your base. (More like the older X-Coms in that you have multiple squads you can send out on sorties; also multiple bases.) Your equipment is largely what you find out there, from guns and ammo to vehicles and gasoline to building materials, and it has to be carefully rationed. Rangers that get wounded have to get medical attention for a while just as in XCOM. You earn support from settlements, which take the role of continents in XCOM – difference being, of course, that you start out with no help from most of them and have to earn it (once you actually discover the settlements, which are mostly randomly placed) and not just vice versa. Sometimes support from settlements is mutually exclusive as one faction hates the other, and thus, the perks you get are different.
Additionally, enemy strongholds may require multiple strikes from patrols to clear, and may regenerate over time, so you'll want to coordinate your strike teams and possibly take advantage of different vehicles to finish off an enemy base. (Say you get a helicopter working – you hit the robot base with all of your patrols, and then send the first patrol back to the target in a helicopter to finish it off before it builds any more new robots.)