Thought of this last night while making a midnight snack.
tl;dr: Amnesia with serial killers.
Long version: You witnessed a massacre several years ago perpetrated by a bunch of deranged psychotic thrill killers. They were supposed to be locked away for life, but escaped from prison and find you before you can be placed in protective custody.
Now, your character is a handyman. As you flee from the murderers, you can build and set traps (nonlethal), barricade doors and windows, use tools to bludgeon your pursuers, and so on. You can also exploit the psychosis and phobias of the thrill killers; for example, one of them might be afraid of his own reflection, so startling that guy with a mirror might give you a few precious seconds to escape before he smashes it. There would be a number (possibly a dozen or so) of unique killers, and you'd have to discover the best ways to avoid and evade them. Of course, certain techniques wouldn't work with everyone; a clown wielding a chainsaw would not be greatly slowed by a sheet of plywood over a window, but perhaps placing a baby doll in a visible location would cause him to go after it instead (after all, he was a child killer).
It all boils down to if you can survive, and how. Perhaps multiple endings depending on if you used your tools, played mind games with the killers, if you actually killed them, if you saved your family as well, etc.