Sniff... That article was beautiful....
And yes, caffine and sugar are probably not the healthiest diet but most programmers/mathmatician types seem to need them. Toady knows it could be a problem and can watch it himself! Debating sugar nutrition is futile as there is so much contradictory information out there!
Back on topic, looking at that "three bites" thing; I really hope that "Interaction effects" will be dealt in something like doses that can (but not neseccarily will) decay over time if not at the point of a self-sustaining infection instead of a flat "X exposures" rate. More complicated, yes; but ultimately more FUN!
Urist Mc1, Mc2, and Mc3 are all maulled by werewolves.
Mc1 is fine afterword, didn't get much contact. Any traces of the "interaction" except normal injuries fade over time.
Mc2 has a weaker than average resistance to it and never actually goes back to a "clean" state, allways with say, 12 units of werwolf curse out of 100, giving him a slightly raised lower cap on strength and hairyness, etc(hard to see on a dwarf!) but not at a level where it will ever progress further. Later exposure will add to that 12 though, and if it reaches critical mass at 20 for him because of his weak resistance, or if something else weakens his supernatural "immune system"...
Mc3 got up to 24 units, and for a while it looked like he would pull through. He recovered from his injuries and was, a few weeks later, examined again. 26. Uh oh. After more observation it was confirmed as still steadily climbing -- 30 now and accellerating. Exponentialy. Better hurry up with that cage, he's behaving even more erraticly than most dorfs, throwing temporary berzerk fits when in combat as he has dificulty recognizing friend and foe! For a while he might be usefull as a mighty warrior that even (occasionaly) listens to your commands, but eventually he is going to shapeshift completely and start eating your dwarves.
...Looking at the epic extremes we Bay12ers take everything to; I can see adventurers somehow raising thier resistance to curses/whatever and going on a spree of giving themselves a critical dose of everything potentially advantagous generated in thier world. Picture an adventurer with one tentacle limb, patches of scales, assorted body deformities from all the conflicting templates, sharp horns...
At some point NPCs should become hostile though. Letting an adventurer given a patch of scales on his arm from too much contact with demon blood into the inn? Maybe. Abovementioned monstrosity? Just another monster. KILL IT! Then again, early stages of, say, vampiricism should be easily hidable.