The "no infinite experiment repeats" sound like they're going to make science a lot more painful to happen. No more queueing up dozens of transmissions simultaneously while passing through high atmosphere. Also, no more gathering science from multiple sciomes with the same vessel
Actually, it sounds like instead of repeatedly transmitting from 1 biome, you will be able to gather multiple biome experiments with 1 vessel as long as you collect and store with EVA. Much better then repeatedly mounting slightly different missions to the same planet.
Take for example a Science Jr, and land it on Eve. If you bring an antenna and a solar panel, you can get 20 transmissions each from Kerbin's surface, low/high Kerbin atmosphere, low/high Kerbin orbit, high over the sun, high/low Eve orbit, high/low Eve atmosphere and Eve's surface. That is a fuckton of science you get there: around 1900, using just the Science Jr.. I unlocked almost the entire tech tree in only six missions (landing pad sample, Mun orbit/return, Mun landing/landing/return, Minmus landing/return, a Moho orbit and an Eve landing), and I don't see how that's grindy at all, since I don't really need to go to the same place twice. Now imagine how much science I would not be able to gather at once if the science modules weren't infinitely resettable (or at least not without the occasional EVA). I couldn't do the atmosphere samples, I'd need to EVA a few times in every other sciome, and the science I'd get from Moho or Eve would be further decimated because I can't return the science completely. This would essentially mean that I wouldn't get enough science on the first trip to the planets, necessitating second and third trips just to get enough science to unlock the necessary parts for the fourth and fifth trips. I really don't see how that's better than before.