Depends on the goal of a character. A minimum of 11 INT was always required if you wanted to be able to read all the books (as that's the lowest INT you can have for a hit of Adderall to push it high enough). Mostly I tend to go for a balanced build; the current build I'm playing is actually a straight 10 across the board. Quick is pretty much required, and I've always liked Packmule; two backpacks + Packmule usually means you'll hit the item limit before you run out of volume unless you're trying to move steel frames or something. Pain Resistance as well, as it tends to give you a bit of an edge in bad situations. I tossed in Night Vision and Disease Resistance because I had a spare 2 points to spend and they both are helpful in their own ways, now that colds and the flu are real issues. If I put anything into skills, it'll be a level of dodge. My normal list of negative traits are: Near-Sighted, Heavy Sleeper, Glass Jaw, Trigger Happy, Wool Allergy, Truth Teller, and Ugly, as they're all relatively minor. Hell, I see Heavy Sleeper as a positive trait; I used to play with Insomniac and it pissed me off so much.
Speaking of my current character... Just found a bunker about fifteen map tiles outside of a city. Got a decent haul of food and water, as well as a pair of M4A1s, a SCAR-L, a SCAR-H, ~100 rounds of NATO and IC ammo for each, a fusion rifle, and a shitload of silencers and extended clips (well, once I manage to find enough milids to open everything). A short walk east is a metal wreck that had 4 CBMs. Looks like New Base Get.