Edit: Just in case you were thinking "Oh, I know how to set up graphics options, I do that in every game I play", here's the setup for generally-agreed-upon-as-best graphics plugin for epsxe.
I see one open menu with nothing checked on it (almost certainly contains game-specific configuration options that you almost certainly don't have to worry about), one menu containing keybindings for common functions, one text input that can (apparently) be left as default, a video plugin selector whose only important option is the simple drop-down menu, and finally a single menu with a handful of options, most of which are either specified by your monitor settings (resolution), are strictly optional (FPS display, screensaver disable, etc.), or are more or less a case of "what is your GFX card capable of?"
I don't see much to panic over. No offense, but I wouldn't try to discourage someone from using Win7 by opening the Control Panel, Windows Explorer, and a couple of command windows and exclaiming, "Hey! Windows is totally complicated! Really!"
That's not quite how it works. The majority of the drop down menus aren't exactly linear "bad graphics to good graphics" and many can have a negative impact when combined with other features, a lot of them need to be tweaked based on what shaders you're using, and what game you're playing (specifically if it's 2D, 3D, a mixture of both, rendered backgrounds, cell shading, etc).
I was trying to give a feel of how complicated epsxe is compared to not having to set up anything at all, as is the case with pSX emulator. Obviously, I did not do a very good job.
I do encourage you, however, to try selecting shaders yourself and setting them up to work optimally in a game yourself using epsxe. I can't properly convey the confusion of searching for hours through years-old threads referring to plugins that are outdated or no longer hosted in a screenshot.