I'unno, when I was playing thorium the storage/inventory management didn't really feel much different than vanilla. There's more, so obviously there's going to be more storage, but it's not particularly out of line compared to the base game.
Normal tote around by the end was whatever weapons I felt like using, maybe one swap in armor set (on top of the two you can wear), stack of health pots, stack of buildy stuff, and the miscellany (mirror, maybe fishing, various detection junk, maybe another weapon or two (usually summons), maybe another accessory or two, etc.). Torch somewhere in there. Toolbar was generally full, along with the 2-4 columns on the left of my inventory, leaving a bit over half-ish free to fill with junk. Which is more or less exactly what my vanilla end-game looked like. Thorium introduced maybe a half column or column worth of extra stuff-I-carry-around and it could have totally been significantly fewer if I hadn't been perpetually tooling around with new junk.
Now, junk wise thorium does introduce a buncha' crap one only need one of two sets of, so there's more stuff-you-pick-up-exploring-that-you-trash-or-vendor, and you'll probably have another chest or three for mod stuff, but... I didn't much feel the need to go substantially out of my way to accommodate it. Like said, inventory wise you might have 3-6 ish new stickarounds (and some stuff gets replaced or compacted, so the net increase may be smaller) and storage wise you'll want a few more chests than you otherwise would, but that's about it. 'Bout the same amount of pressure, more or less.
... though yeah, if you felt constrained by vanilla terraria's inventory, thorium certainly isn't going to be better. If trashing stacks of building material or obsolete/unneeded cruft when you're meandering around bothers you you're in for a bad time.