I would personally go with antihydrogen, compressed to a metallic state. (Hey, if you have the ability to come up with that much antihydrogen, I would expect that compressing and containing it wouldn't be very much of a problem.)
Here's my projections.
1. Release
2. Annihilation begins, producing 2 gamma rays and 2 high energy pions, remaining heat energy per atom annihilated. (Another reason I'm going with antihydrogen. Known annihilation products.)
3. Now, initially, only the surface layers annihilate, but that's the good part of using antihydrogen; it will expand into a gas with much enthusiasm, thus mixing better.
4. A gamma ray pulse is released, flashing the atmosphere surrounding the initiation* into plasma. It also flash-heats the now-plasma and all other gamma ray absorbtive objects nearby. (basically, everything conductive.) It's true that this energy transfer is not very efficient, but keep in mind, we are dealing with a LOT of energy (2x10^16J) in total here...
5. Now, pions don't really interact with macroscale matter very much (their interactions are of the strong nuclear force, so they have to pass within femtometers of an atomic nucleus to have any effect), but there'll be so damn many of them (13.6x10^28 of them), that they'll inevitably leave a good chunk of energy in the plasma, heating it further and giving it that all-important shockwave. The shockwave travels out at hypersonic speeds.
So, end effects:
-Gamma ray pulse. Will probably roast everything within a couple hundred kilometers, fatal irradiation in line of sight and probably a few degrees past the horizon. Damage radius: Approximately 7km at ground level, radiating out into space. Will likely damage satellites.
-Plasma cloud, largely incidental, but will consume anything left by the gamma ray pulse, partically organic items (if there's anything left by the gamma rays, anyway.) Damage Radius: Approximately 5km. Contributes directly to shockwave.
-Shockwave at probable speeds of several of hundreds of kilometers per second, if not low thousands. Will flatten buildings, trees etc. Damage radius: Worldwide. May** deform atmosphere sufficiently to deorbit low earth orbit satellites and debris directly above initiation.
*Not an explosion, strictly speaking. An explosion can be summed up as 'combustion, confinement, explosion'. No combustion involved, no explosion. Same is true of nuclear 'bombs' (devices), they don't explode, and they're not bombs in the standard definition. But eh.
**Guess. A shockwave does not move the medium it is travelling through in any significant manner, but the heating and production of plasma in the immediate area may cause sufficient displacement of air to result in that.
Disclaimer: I'm sure of the interactions, (as in, mechanism of gamma rays producing a plasma cloud and how a shockwave would result) however, the energy transfer issues are rather iffy. I'm using a rough guide of 1% energy transfer for the rest of the calculations.