Converted my main industrial base into an all-in-one by tearing everything down and rebuilding it as one big tower. In the process, I mostly figured out the pathing tolerances for most big Pals, such as Reptyro
*, Helzephyr
*, and Selyne
*. Particularly giant Pals, such as an Alpha-sized Jormundtide, are probably too large, unfortunately.
Basically, most Pals can handle pathways one tile wide, but I went with two-tile paths and stairways. I did learn that Pals can't path upstairs unless every tile above each stair is empty - since my stairs are two tiles wide and three walls high, I need a 2x3 hole in the floor over the stair in order to path up and down the stairs.
I have the tower arranged thusly: the ground floor is where I have the mines, farms, power production, refineries, and main storage(as well as the Palbox console). There is also two oil wells, but powering one pump takes an extreme amount of power. Second floor is where all the beds, hot springs, and food prep areas are. Third floor is where both manufacturing and the medical and research centers are. The med/sci section is where all the egg incubators, medicine production, and Pal condenser is located.
The rooftop is where I have the Ranches and Breeding Farms, plus the expedition platform since all of these are too large to easily put them anywhere below. I used the remaining space to build myself a small house.
Took me a few days, and so much metal and stone that trying to restock on ingots got me the Iron Heart achievement.