Fallout 3: Very first 3D Deathclaw encounter (played Fallout 1 and 2 before, beat FO1. I'm familiar with the danger level of these things), at character level 7. Though it was already wounded when I ran into it, and found a poor sap already killed by it, I successfully snuck up behind it and power-fist knocked off it's head. It came included (at least it came with the SOL adventurer dude) the schematics to make use of it's claw as a weapon. Got another one later at Rivet City, and manufactured my curb-stomping weapon of mass destruction.
Immediately after, I took on the Nuka-Cola challenge, and immediately KO'd numerous Nuka-Cola Protectrons and Nuka-lurks. Although near the end of the quest at the Nuka-Plant, I also ran past a pack of Nuka-lurks (approx. 4-6 of them; low on health, and really stingy with my 60+ stim-paks), and killed off one that was trailing me while I had less than 30HP into the next sector. Killed off the remaining Protectrons, and completed my goal there. I intend to return to finish off the remaining Nuka-lurks.
Sure, I drank plenty of cola and ate some radroach meat and such to heal, but no stim-paks.
I love my Deathclaw Gauntlet. ^_^
In my travels, I quickly took the face off of a super mutant (at least the blood covering the face looked like it) in about 3 hits. Mind you, still at level 7. And all this is with an optimized small arms ranged character, and they're thrashing many armored guys like their armor was made of warm butter.