The government of Pakistan has officially demanded that the United States
withdraw over 300 CIA agents and contractors stationed in Pakistan, virtually the entire American intelligence presence, including adjunct-advisers to the Pakistani military. This follows a still very murky event in which an undercover CIA operative shot and killed two Pakistani men, possibly undercover ISI agents, in a bizarre
Reservoir Dogs meets
Burn After Reading style altercation.
Naturally, almost nobody in Pakistan actually trusts the United States, partly for all the normal conspiratorial reasons, and partly for the very real relations disaster of the US's strategy of using drone strikes from Afghanistan to target enemy agents in northern Pakistan, causing a tremendous amount of collateral damage. It should be noted that President Obama authorized more such drone strikes in his first year in office than President Bush did in seven. Naturally, the Pakistani government is in a lot of hot water with its own people for "allowing" this. Not that they need a reason to be conflicted - the Pakistani military/security apparatus has always considered India its most important concern, and has throughout modern history liked having the various Afghan militant groups on speed-dial as a bludgeon, overtly or covertly.
Needless to say, this is a pretty significant turning point in a war approaching its tenth year, with no clear goal in sight. Pakistan has been essentially the equal second front of that war, and the actual government there has declared the American force persona non grata.