I'm totally tempted to do some really strange shit with an idea I had.
Amorphous Plus + Jojo's Bizarre Adventure + the contents of recent ideas
You're a settler for the colonization of a new planet, when suddenly aliens, blah blah haven't plotted the plot...
You have to clear out hives of various amoeba-like creatures... except for the fact that they're easily mutated and come in thousands of species, each successive one seemingly more and more dangerous. You'll get quite a few toys to help you clear a nest, but mainly, you'll have:
Armor Abilities, one for your Legs, Arms, and Torso. These will make you more able to survive in a hive, by protecting you from the various attacks that the enemy amoebas have.
Your other key item is your Big Fucking Sword. While that's not the technical term, it's a very good description. All the swords are huge, and you need the power armor to lift them. Even with that, they can feel heavy, like a sword should.
You've also got three slots for Equipment. This can be anything from a one-use item to a drone or something. I have a few in mind, might list them later.
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As far as enemy types, you start with the weakest of them all: the Drone. It can't damage you, dies in one hit from practically anything, the only thing it can do to you is bump into you on accident and cause you to stumble, and it's barely able to do that. Most of the time, they pass you by without doing anything.
A good example of a normal enemy is the Roller. They've got hard shells, and roll after you in an attempt to knock you over. They're not really that good at killing things, and unless you're already injured they won't be able to, but they are capable of doing some damage.
A lethal enemy to fight is the Biter. Similar to a roller, but they're softer. They also have sharp teeth bristling out of their membranes. Their signature is to lunge at you, teeth bared, and if you're unarmored and can't block or strike before it hits you're as good as dead. They don't actually eat you, their teeth are for defending the hive.
An advanced enemy would be the Hunter. These guys are Biters, but more evil. First, they're hairy. Their thick fur makes it hard to land a square blow to their body, and your sword will have to strike more than once to slay one. They're better Biters, in that they do a biter's job better.
A sub boss enemy would be the Horror. What do you get when you take multiple Biters and stick them together? A Horror. Large blue masses with many, many gyrating teeth, they resemble buzzsaws. They are also able to spit their teeth at a foe, or split apart into four separate disks to surround a foe before reforming around the nucleus. The nucleus is nigh-impervious until it does this, and therefore, is very hard to kill.
A boss enemy would be named "Duke", "Queen", "King", or a similar title followed by the name of the enemy it most resembles. Most bosses are named after Normal class enemies. You may run into, say, a Queen Biter. She would have four toothy disks much like the Horror constantly swirling around her. She'd only drop her guard when lunging for a foe, or possibly if you knock one of her disks into her. She's much like a Horror in that coming into contact with her while she's in the invulnerable state, it's a lethal encounter, although she does not directly copy the gyrating teeth (she simply absorbs you and pulls you in with teeth.
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Say I had:
TORSO: HAZARD suit (Impervious to most of the fluids of Amoebas, such as acids or sticky gel.
ARMS: WILD arms (Better chance to block/counter an attacking enemy, faster sword swings)
LEGS: VANGUARD legs (Being bumped into dosen't steal your next turn.)
SWORD: ZATO-1 (A long, but thin blade. Faster swings, longer reach, less power.)
E1: BOXGUN (A backpack-sized box that folds out into an automatic, .50 caliber turret. Fires somewhat slowly, but won't/can't be damaged by many things and is steady for as long as it has ammo. Explodes when it runs out of ammunition. Recharges.)
E2: REACT TRAP (A grenade that releases aerosol-based bait. When attacked by an attracted amoeba, it explodes. Recharges.)
E3: BLADE PLUS (Removes limits of the blade you're using, as well as the interface between it and your arms. Temporarily allows for instant-kill slashes and special maneuvers, but steals a turn when it runs out. Recharges.)
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The items that recharge (multiple uses) that don't seem to make sense use a GPS tracker and the Homeland's (your colony) ability to teleport items to replenish your stock when able.
You'd work in a team of 4. Other systems:
Health:
Godly- One step above Healthy, this can only be achieved with certain equipment, or other means (adrenaline rush when at full Health, possibly.) Any successful attack leaves you at Healthy, even if it was to be instantly fatal.)
Healthy- Normal. No penalties, no gains. You feel pretty good.
Nominal- You maybe have a slight bruise. No penalties. You feel OK. Very rarely will this happen, unless you get bumped into a lot.
Injured- You've been wounded, but you can still fight. -1 to all actions until you're healed or get a natural 6 on an attack roll. Get a 1, and you'll injure yourself further.
Critically Wounded- Unable to act, unconscious, or severely mangled. Near death- roll a d6 every turn. 6= move up to Injured, 1= Dead. Being attacked while in this state is lethal.
Dead- You Are Dead.