What got me nearly through the whole game was :
Rush -> Axe Kick (big damaging kick in the face, get combo points, make enemy fail talents) -> regular punching (to benefit from automatic Double Strike and get combo point) -> Haymaker (finisher with devastating damage , remove combo points) -> Flurry of Fist (3 punches, get more combo points) -> Concussive Punch ( finisher with big damage with large area of effect to deal with groups, remove combo points)
and get an Uppercut to stun people if you think you need that.
Assuming you have good equipment to optimise your critical % and damage output, with Flexible Combat, nearly every regular enemies are dead after the axe kick , rare/unique may be dead after the haymaker and some bosses may be nearly dead after the concussive.
I didn't go antimagic so i could benefit from a shield rune to add to my character resilience, along with a teleport just in case (i don't think i actually used it for the whole game).
On the talent , out of the obvious damage dealers i mentionned make sure to get the ones from Cunning/Tactical to improve everything about your punching in the face and defense.
On the other side, the 2 first talents of Technique/Unarmed training are a must have for tons of STR/CON bonus and big damage bonus
Unflinching Resolve is a must, at max it give passively 59% of chance each round to remove stun/blind/confusion/pin/slow/wound effects you recieve.
I didn't used any of the grappling skills, no idea if they're worth the investment or if they're weak and useless