On topic. You are not insignificant. Perspective is everything. Every perspective is its own universe, with just as much gravity as the objective universe, because without it the actual universe would be nothing. These orders of scale are in themselves something that only exists according to our perspectives, after all. What is an object? It's made of particles, but we see it as the sum of its particles. What is the universe? A bunch of particles. What are we? A bunch of particles. Without your perspective to identify some groupings of particles as different from other groupings of particles, could we even say that there is objectively a universe? There's only a universe to us. Our perspective creates it. Without that, there's just a mass of particles. A single object that without the relativity of human perspective is not even a large object, just an object.
You know what makes me feel insignificant? Thinking about the way everything is made up of systems of particles in ever increasing orders of magnitude, and realizing that I am a particle in some system. Think about cells in your bloodstream travelling through your body to perform various tasks. Now think about yourself driving in your car throughout the city to perform various tasks. If a blood cell were intelligent, how would it feel about knowing that it is actually a part of a larger being? Different groupings of humans have interactions with other groupings of human beings with the actions of individuals adding up to a sum that is greater than its parts, just as the interactions of groupings of particles in our bodies gives rise to us as intelligent beings. Is our intelligence the only kind, or are there more abstract forms that we are a part of? I saw a TED talk a while back where the guy talked about the development of the internet and compared the number and interaction of users, databases, websites, etc to the neurons of a human brain. I can't help but wonder. What is the internet thinking? (I fully expect a slew of internet memes in response to this)
But this is just stuff I dream about for fun. The way I see it, experience is existence, and the only experience we have is our own. So it's impossible to be an aware being and be insignificant. Without you, the universe as you know it doesn't exist.