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[Mephansteras]

You just have to be careful with them. But I use grenades all the time. Especially as mines when running away from enemies. And once you can tinker up a few types they stop feeling special at all and can be used with abandoned.

Besides, it's a roguelike. If you don't use your special stuff when you get a chance, you probably won't live to use them at all!

[Teach]

Problem with the Billowing Conch of Aji is that what comes out of it is random.  You're just as likely to put yourself and the enemy to sleep as you are to summon some hellish 15dmg/turn poison. 

Ego boosters are awesome. (doubles sell values/halves buy value for low ego characters)

The life drain mutation is ridiculously awesome (balanced out by it's melee range though).  It's like setting someone on fire except the damage they take heals you. (for 20 rounds)

At higher levels Cryokinesis "spreads" because it lowers the temp a bunch.  Dunno about pyro.

Bashin nades just cause they don't get thrown any appreciable distance (the HE series seems to have a blast radius that exceeds your range).  Does raising STR/agi increase your range?  I find poison to be way more useful for crowd control, because it does about the same amount of damage overall just in increments so you're less likely to die from it.

[beorn080]

Str modifies throw distance. There was an issue many versions ago where negative str resulted in a large negative throw distance, so you could aim opposite of where you want to go and it goes far. Mines and Bombs are where its though. Acid bombs are amazing for getting through walls.

[Angel Of Death]

I remember fighting my evil twin, we both had the gas mask and poison grenades.  Both of us threw our grenades, then fought in melee.  It was like something out of World War I.

That's awesome!

Oh, btw, how do I eat or drink stuff?

[shaihulud]

you do ithat in inventory, select the item and it will give you the option.

[Angel Of Death]

you do ithat in inventory, select the item and it will give you the option.

Thanks for telling me.

[Teach]

Agreed, once you get Lay mine/bomb 'nades become a hell of a lot more useful.

The problem with grenades is that they are too situational.  I understand that that is the way they were intended to be (otherwise there wouldn't be such a large variety with a multitude of differing uses).  I'm actually fine with most grenades as they all have their niche (acid for walls, emp for robots, ice when you need some space, and poison/thermal just rapes the hell out of mobs) it's the HE nades that usually spell doom for my chrome gilded adventurer.  I'm going to wait for damn perfect conditions next time I decide to use an HE nade. (Salt plains+day time+str 25).  It's usually my inability to keep my hands off those nades that ends me.  My last three characters all died to it even though each time I thought I was being more careful than the last.  I may be hallucinating but I feel like at times the blast from an HE nade gets a little funny.  I don't think that the resultant explosion from a thrown HE nade is entirely uniform when you add tight spaces to equation.  I say this because when I chucked an MKI nade at a chitinous puma who was standing in front of some ruins and the explosion assumed a star shape.  The problem was one of the corners of the star extended out like an arm (consisting of dust, fire, and concussive force) to drag me away to whatever damned place Quddites go when they die.

[Angel Of Death]

What are the best mutations to have?

[FuzzyZergling]

What are the best mutations to have?

Depends on what you want.
I like having Light Manipulation, since it not only lowers the need for a light source but also comes with a pretty good projectile attack. If you spend a lot of time outdoors, then wings are a good investment, though you'll need a ranged weapon to attack ground targets,

[Angel Of Death]

I like sleeping gas generation or any other gas generation. Regeneration's also good.

Also, am I meant to get the Instaheal Autoinjector in Redrock?

[Niveras]

I don't use grenades because they're like, Special Weapons.

You know, those Special Weapons you never use because you're always saving them for something else.

I used a High Explosive Mk3 grenade once.

I decided not to do so again.

What are the best mutations to have?

Flaming Hands is OP. It's seriously a lot of damage for such a short cooldown, such that I expect a nerf. But maybe it's balanced. Freezing Hands could also be situationally more useful - a little bit less damage, but freezing is nice CC. The issue there is that as you increase your Freezing Hands skill it becomes dangerous to strike frozen targets in melee, because temperature "leaks" across tiles. Cryokinesis especially can freeze you once it reaches ~5 points if you're not careful; I'm not sure if that carries over to Freezing Hands. This is true of flaming/pyrokinesis too but bursting into flames from proximity to heat is slightly less dangerous than getting frozen for a turn (or more!) as you wait to heat up.

However, whatever you pick I don't recommend choosing more than two, maybe three, physical mutations, because you can only buff those with mutation points from leveling. You only get a limited number of mutation points, but the leveling scheme is such that you can keep two mutations maxed to your limit. There isn't much [finished] content beyond around 25, so you'll have ~5 "unspent" points... if you survive that long.

That said, some physical mutations don't need to be maxed, or can't be increased anyway. You'll probably want to max any offensive mutations, but something like Photosynthesis only needs a couple points (so that you can stay underground longer without needing a trip back to the surface).

[Tarran]

What are the best mutations to have?

Regeneration is a must have for me. It may simply be just HP regen, but HP regen is always good, especially for melee characters.

Another is either Force Wall or Force Bubble. For obvious reasons.

[Mephansteras]

I'd like to see Night Vision upgradable so I can see further at night. I think how it is at 1pt is fine, but increased viability would be pretty awesome and I wouldn't mind pumping mutation points into it.

[Angel Of Death]

Don't pick 2 types of gas generators on the mutation screen! Only one of them will work.

[beorn080]

Wings is utterly amazing, as long as you stay above ground with it. Once you get it to level 6, you never fall and are incredibly fast and almost never get lost when travelling.

Personally, I prefer freezing hands to flaming. When traveling anywhere with water, especially underground, flaming hands makes giant steam clouds that are really nasty, whereas freezing hands, particularly after about level 5, makes giant swatches of long lasting ice. Which, now that I think about it, doesn't make sense, since we're talking salt water, but then if it doesn't freeze things, it needs a damage boost.