Ok something is either wrong with my characters or with this game.
I made a syzygigor once, didn't even care if he died or lived, and made a speedrun through all the quests. (I searched for stairs only and as soon as I found the girshling and later the wire I always backtracked to stairs, and didn't bother searching the rest of the area)
Went to grit gate, speedrun to entrance, then slash my way in golgotha no problem. Died at bethesta susa.
Then later a mutant character with all stat enchancing mutations (the stats of a mutant are actually higher than true humans because of that)
He has real trouble surviving now. Getting confuzed from witchwood and small amounts of it for healing don't help.
I had to cheat to get the scrapped waydroid, since everything killed him so easily.
I think True humans even with actually lower stats (stat enchancing mutations are OP btw) have hidden bonuses or something.
A hint to everyone: pick a defect and distribute the points and delete the defect, you'll be at -4 points and unable to progress. Now if you press "walk northeast" you'll end up at class picking screen, and now you're at +4 points than you would be normally.
Also on defects:
Plenty of them are actually beneficial/not that harmfull.
Amphibious says that you need submersion in fresh water. What it actually does is let you stand around in water and "drink" it. When you drink water when amphibious you "pour" it on yourself. You also can go longer periods of time without water. "P"ouring salty and brackish water on yourself will fully fill you up. This way you can use fresh water for trading, and use the common salty water for drinking instead. See? Advantage labeled as defect.
Other beneficial/not harmfull defects:
Brittle bones - never seen a broken bone and you can buy a skill to fix them
Hooks for feet - even with fullerite boots you are only losing 3av tops
Ravenous - food is plenty
Blinking tic - looks like random teleporting in ADOM. While annoying it should in theory actually help you escape danger
Socially repugnant/albino - seems to only be a negative ego while trading