Hacked apart by Captain Mathias in Dead Space. I was even still at about 75% health. Impossible difficulty is no joke.
I've beaten impossible difficulty once before on the console version many years ago, and after playing through hard mode on the PC a few weeks ago I figured I'd give impossible a shot. I was expecting more difficult than I got. I beat hard mode while only dying twice, both times to the lockdown area in the Valor's barracks due to running out of ammo and not having time to reload before exploders got too close. However, I ran out of ammo in chapter 1 a couple of times on hard mode and had to resort to melee, which is dicey even on easier difficulties.
Impossible hasn't been so bad. I finished chapter 1 with more than 50 shots of plasma energy and didn't die once, due to much abuse of stasis and melee and running back to the tram area repeatedly to recharge stasis to save ammo.
I've died twice in chapter 2 though, since even mook slashers do ~50% damage with one hit and two slashers killed me when my cat got in the way. Then I screwed up on the captain when I missed the infector with stasis, leading to a panic as I tried to stop it from infecting more corpses and Mathias sneaking up behind me and killing me in 1 hit. Next attempt went much better, with no damage taken.