T15 map, doesn't have too nasty mods but you still gotta be extremely careful. Run into a triple essence yellow beast, now, I can facetank and leech up trough most of the damage, but at certain points all of its fucking effects from the added mods overlap and i'm just erased, all the dodge, evasion, resistance, blocking and 6k hp meaning sweet fuck all. Luckily the poison I stacked on it got it in the end, not before losing 3 portals to it :V
Afterwards I lose the map completely because it has a no-regen mod, which means the only way I can get mana is by hitting things, at melee range. Now I don't have mana flasks because I almost never need them, in this case I had no mana so I couldn't shield charge into a pack of ranged mobs which were capable of one-shotting me by sheer number of shit they'd fire as I was approaching them, and they were guarding the only narrow bridge towards the rest of the map. So I tried walking into them regular way but I was dead about halfway there :V
Path of Exile
Edit:
Adding this because it's fucking irritating that it's happened the exact same way twice now. Having a good and balanced match as pally against a mage in arena, but then they drop that goddamn kabal courier and get the fucking frost lich jaina. At that point you really can't win anymore because you have lost your hero power and they have a dumb amount of healing and board control now.
What's the point of pulling a card from the draft if you can still just discover it from any of the billion random card generating things present in the game.
Hearthstone